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American Society of Microbiology ABMM Sample Questions:

1. A research team is investigating the mechanism of bacterial resistance to a novel fluoroquinolone antibiotic.
They isolate a resistant strain of Escherichia coli from a patient with a urinary tract infection. Genetic analysis of this strain reveals a point mutation in the gyrA gene. This mutation MOST likely results in:

A) Modification of the ribosomal target site, preventing antibiotic binding.
B) Increased expression of efflux pumps that actively transport the antibiotic out of the cell.
C) Alteration of the DNA gyrase enzyme, reducing its affinity for the fluoroquinolone.
D) Production of an enzyme that inactivates the fluoroquinolone molecule.

2. A patient with a history of travel to South America presents with fever, lymphadenopathy, and hepatosplenomegaly. Peripheral blood smear reveals the presence of trypomastigotes. The MOST likely diagnosis is:

A) Malaria
B) Leishmaniasis
C) Chagas disease (American trypanosomiasis)
D) African trypanosomiasis (sleeping sickness)

3. A patient presents with a chronic cough, weight loss, and night sweats. Chest X-ray shows cavitarylesions in the upper lobes. Sputum is acid-fast positive. Drug susceptibility testing reveals resistance to isoniazid but susceptibility to rifampin, ethambutol, and pyrazinamide. The MOST appropriate treatment regimen should include:

A) Rifampin, ethambutol, and pyrazinamide
B) Isoniazid and rifampin
C) Isoniazid, ethambutol, and pyrazinamide
D) Isoniazid, rifampin, pyrazinamide, and ethambutol

4. A patient with HIV infection and a CD4+ T-cell count of 30 cells/µL develops progressive multifocal leukoencephalopathy (PML). The causative agent of PML is:

A) JC virus (JCV)
B) Human herpesvirus 6 (HHV-6)
C) Cytomegalovirus (CMV)
D) Epstein-Barr virus (EBV)

5. A patient presents with a pruritic rash consisting of raised, serpiginous tracks on their skin. The patient recently returned from a Caribbean vacation and reported walking barefoot on the beach. The MOST likely causative organism is:

A) Larvae of Ancylostoma braziliense
B) Sarcoptes scabiei
C) Pediculus humanus
D) Larvae of Strongyloides stercoralis

Solutions: